Survived Despite High Creatinine

A patient with Graves' disease who survived despite developing thyroid storm and lactic acidosis

A 56-year-old woman with Graves' disease presented with the complaints of diarrhea and palpitations. Physical examination and laboratory data revealed hypothermia and signs of mild hyperthyroidism, heart failure, hepatic dysfunction with jaundice, hypoglycemia, and lactic acidosis. The patient was diagnosed as having developed the complication of thyroid storm in the absence of marked elevation...

Creatinine determined by "high-performance" liquid chromatography.

We describe a "high-performance" liquid-chromatographic procedure for determination of creatinine in serum. Creatinine is separated from other species by cation-exchange chromatography. Absorbance of the creatinine in the eluate is monitored at 234 nm. Results from this procedure on sera correspond closely to those of a manual Jaffé-reaction procedure involving use of a protein-free filtrate wi...

High creatinine 6 months after renal transplant.

A Surviving Patient with Record High Creatinine

Creatinine is a product of muscle protein breakdown cleared by the kidneys at a constant rate. The glomerular filtration rate is estimated based on serum creatinine. There is no definitive level of serum creatinine which is itself incompatible with human survival. We present the highest serum creatinine associated with survival based on a thorough review of the literature. A 34-year-old male pa...

13. Point-of-Care Creatinine Testing in High-Risk Patients

In some circumstances, a creatinine check at home instead of a complete clinical control could be sufficient for patients with renal disease. Home monitoring of serum creatinine concentrations could, for instance, be useful during insecure periods after kidney transplantation, or to keep a close watch on possible disease recurrences. Below we describe a pediatric case of recurrent hemolytic-ure...